The ESMO magnitude of clinical benefit scaling tool: from theory to practice
نویسندگان
چکیده
منابع مشابه
The ESMO magnitude of clinical benefit scaling tool: from theory to practice.
Notwithstanding this, our population-based cohort provides ‘real world’ outcomes demonstrating improvements in survival for patients under-represented in clinical trials. Outcomes from our population-based study of older patients diagnosed 1997–2012 appear comparable with recent phase II studies of selected ‘fit’ patients [2, 5]. These single-arm studies again may reflect improved patient healt...
متن کاملESMO-Magnitude of Clinical Benefit Scale version 1.1.
Background The ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS) version 1.0 (v1.0) was published in May 2015 and was the first version of a validated and reproducible tool to assess the magnitude of clinical benefit from new cancer therapies. The ESMO-MCBS was designed to be a dynamic tool with planned revisions and updates based upon recognition of expanding needs and shortcomings identifi...
متن کاملComment on ESMO Magnitude of Clinical Benefit Scale.
We find the Magnitude of Clinical Benefit Scale (ESMO-MCBS) developed by Cherny et al. [1] a practical and simple-to-use tool for comparing the benefits of new cancer therapies. With a large number of oncology drugs being approved, this kind of rating of the expected treatment benefits is indeed relevant, and we commend the authors for making an important contribution. Cherny et al. propose tha...
متن کاملDetailed statistical assessment of the characteristics of the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS) threshold rules
BACKGROUND The European Society for Medical Oncology (ESMO) has developed the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS), a tool to assess the magnitude of clinical benefit from new cancer therapies. Grading is guided by a dual rule comparing the relative benefit (RB) and the absolute benefit (AB) achieved by the therapy to prespecified threshold values. The ESMO-MCBS v1.0 dual rule e...
متن کاملApplying the ESMO-Magnitude of Clinical Benefit Scale in real life
Correspondence to Dr Fortunato Ciardiello; Fortunato.CIARDIELLO@ unina2.it Our level of understanding of the biology of cancer at this point in time is amazing and continues to increase. Each year we know more and more about the fundamental mechanisms of tumour growth and progression of the disease. Thanks to this improved knowledge we are able to evaluate new drugs that in some instances are v...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2015
ISSN: 0923-7534
DOI: 10.1093/annonc/mdv367